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DECHA DECHTRIRAT

DECHA2 email: fscidcd@ku.ac.th
Education: B.Sc.(Chemistry) Kasetsart University, Thailand.
M.Sc.(Chemistry) Freie Universitaet Berlin, Germany,
Dr. rer. nat. (Bioanalytical Chemistry), Universitaet Potsdam, Germany
Research interests: Biosensors, Biomimetic functional materials, Molecularly Imprinted Polymers (MIPs).

Nature has created molecular recognition elements mainly based on amino acids and nucleotides as biopolymers typically with high affinity and selectivity against their molecular targets. As an alternative to evolution by the natural selection process, fully synthetic molecularly imprinted polymers (MIPs) have broken new ground with promising recognition capability, improved stability, reasonable cost, and rapid manufacture. Molecular imprinting is a strategy to prepare a synthetic molecular recognition unit by polymerizing functional monomers in the presence of a target molecule as a template. Functionalities on the surface of the molecule to be imprinted initially interact with complementary chemical groups of the surrounding functional monomers in a three dimensional space. The resulting structured orientation has to be conserved by polymerization of the functional monomers yielding to a formation of a size, shape, and functionality specific binding pocket after the template is removed (Figure A). A wide range of applications in the areas of chiral separation, selective enrichment/extraction of active compounds from natural products, environmental monitoring, waste treatment, food/crops control, and medical diagnosis are of great interest in our research unit.

Our recent research efforts emphasize on the development of biomimetic sensors for selective detection of proteins. A novel strategy to prepare a selective imprinted nanofilm directly on the gold based transducer surface has been successfully established (Figure B). The resulting imprint shows high discrimination towards the target’s analogues (Figure C).

Selected Publications

1. Hybrid material for protein sensing based on electrosynthesized MIP on a mannose terminated SAM, D. Dechtrirat, N. Gajovic-Eichelmann, F. F. Bier, F. W. Scheller, Advanced Functional Materials, 2014, doi: 10.1002/adfm.201303148

2. Electrochemical displacement sensor based on ferrocene boronic acid tracer and immobilized glycan for saccharide binding proteins and E.coli, D. Dechtrirat, N. Gajovic-Eichelmann, F. Wojcik, L. Hartmann, F. F. Bier, F. W. Scheller, Biosensors and  Bioelectronics, 2014, 58, 1-8.

3. Protein rebinding to surface confined imprint, D. Dechtrirat, K. J. Jetzschmann, W. F. M. Stöcklein, F. W. Scheller, N. GajovicEichelmann, Advanced Functional Materials, 2012, 22(24), 5231-5237.

4. Acidic and basic deprotection strategies of borane-protected phosphinothioesters for the traceless staudinger ligation, M. Mühlberg, D. Jaradat, R. Kleineweischede, I. Papp, D. Dechtrirat, S. Muth, M. Broncel, C.P.R. Hackenberger, Bioorganic & Medicinal Chemistry, 2010, 18, 3679-3686.

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